Neurobiology of Disease Aberrant GABAA Receptor Expression in the Dentate Gyrus of the Epileptic Mutant Mouse Stargazer
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چکیده
Helen L. Payne,1 Peter S. Donoghue,1 William M. K. Connelly,2 Sabine Hinterreiter,3,4 Priyanka Tiwari,1 Jane H. Ives,1 Victoria Hann,1 Werner Sieghart,3,4 George Lees,2 and Christopher L. Thompson1 1School of Biological and Biomedical Sciences, Science Research Laboratories, Durham University, Durham DH1 3LE, United Kingdom, 2Department of Pharmacology and Toxicology, Otago School of Medical Sciences, University of Otago, Dunedin, New Zealand, 3Centre for Brain Research, Medical University Vienna, A-1090 Vienna, Austria, and 4Section for Biochemical Psychiatry, University Clinic for Psychiatry, A-1090 Vienna, Austria
منابع مشابه
Aberrant GABA(A) receptor expression in the dentate gyrus of the epileptic mutant mouse stargazer.
Stargazer (stg) mutant mice fail to express stargazin [transmembrane AMPA receptor regulatory protein gamma2 (TARPgamma2)] and consequently experience absence seizure-like thalamocortical spike-wave discharges that pervade the hippocampal formation via the dentate gyrus (DG). As in other seizure models, the dentate granule cells of stg develop elaborate reentrant axon collaterals and transientl...
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29 The Noda epileptic rat (NER), a Wistar colony mutant, spontaneously has tonic– 30 clonic convulsions with paroxysmal discharges. In the present study, we measured 31 phasic (I phasic) and tonic γ-aminobutyric acid A (GABA A) current (I tonic) in NER 32 hippocampal dentate gyrus granule cells (DGGCs) and compared the results with 33 those of normal parent strain Wistar rats (WIS).
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تاریخ انتشار 2006